Stem Cell Center

Our Stem Cell Center specializes in regenerative medicine and cellular therapies, using the latest advancements in stem cell research. We offer a multidisciplinary, patient-focused approach aimed at not only treating symptoms but also repairing and regenerating tissues for chronic, degenerative, and autoimmune conditions.

At Biruni Hospital, our focus is on mesenchymal stem cell (MSCs) due to their proven safety profile, versatility, and ability to reduce inflammation and promote tissue repair in a wide range of clinical conditions.

Clinical Applications of Stem Cell Therapy at Biruni Hospital

Our Stem Cell Center offers a variety of advanced treatments across numerous medical fields. Below are the primary areas in which we are seeing promising results.

Neurological Disorders

Neurological diseases cause damage to nerve cells and brain tissue that is often irreversible with current treatments. Stem cell therapy offers new hope by aiming to regenerate nerves and protect brain function.

1. Parkinson’s Disease (PD)

A progressive disorder caused by the loss of dopamine-producing neurons in the brain, leading to tremors, stiffness, and difficulty with movement and coordination.

 How stem cells help:

Stem cells can potentially develop into dopaminergic neurons (the cells lost in PD),replenishing dopamine levels. They also reduce neuroinflammation, which helps protect remaining neurons. This may improve motor function and reduce tremors.

2. Alzheimer’s Disease (AD)

A degenerative brain disease characterized by memory loss, cognitive decline, and buildup of amyloid plaques and neurofibrillary tangles.

How stem cells help:

Stem cells may reduce amyloid plaques and brain inflammation. This could slow cognitive decline and protect neurons from further damage.

3. Multiple Sclerosis (MS)

An autoimmune disease where the immune system attacks the protective myelin sheath around nerves, causing communication problems between brain and body, leading to muscle weakness, numbness, and fatigue.

How stem cells help:

Mesenchymal stem cells (MSCs) can modulate immune responses to reduce autoimmune attacks, and promote remyelination (repair of myelin sheath),potentially slowing progression and reducing relapse frequency.

4. Amyotrophic Lateral Sclerosis (ALS)

A progressive neurodegenerative disease that destroys motor neurons, causing muscle weakness, paralysis, and respiratory failure.

How stem cells help:

Stem cells may deliver neurotrophic factors (growth factors for neurons) and reduce inflammation, helping to preserve motor neuron function and delay disease progression.

5. Cerebral Palsy (CP)

A group of disorders caused by brain injury or abnormal development, often during birth, leading to impaired movement and muscle coordination.

 How stem cells help:

Stem cells can help regenerate damaged brain tissues caused by oxygen deprivation or injury, potentially improving motor function and muscle control.

6. Cerebral Ischemia (Stroke)

Occurs when blood flow to part of the brain is blocked, causing tissue damage and loss of function such as paralysis or speech difficulties.

How stem cells help:

Stem cells promote angiogenesis (formation of new blood vessels) and neurogenesis (generation of new nerve cells),which aid recovery and improve neurological function after stroke.

7. Paralysis (Spinal Cord Injury)

Paralysis (Spinal Cord Injury) is the loss of movement and sensation caused by damage to the spinal cord. It can be partial or complete and may affect the lower body or all four limbs, depending on the injury’s location.

 How stem cells help:

Stem cell therapy supports nerve regeneration, reduces inflammation, and creates an environment conducive to repair, potentially enabling partial recovery of movement and sensation.

2. Eye Disorders

Degenerative eye diseases often lead to progressive vision loss or blindness due to damage or death of retinal cells or optic nerves.

Retinitis Pigmentosa

A genetic disorder causing gradual degeneration of photoreceptor cells (rods and cones) in the retina, leading to night blindness and tunnel vision.

How stem cells help:

Stem cells may replace the lost photoreceptor cells, preserving remaining vision or even restoring some sight.

Optic Atrophy

Optic atrophy is the damage or degeneration of the optic nerve, leading to partial or complete vision loss. It can result from eye diseases, brain or nerve injuries, or other conditions affecting nerve function.

How stem cells help:

 Stem cells may help regenerate damaged optic nerve fibers, improving signal transmission from the eye to the brain and enhancing vision.

Age-related Macular Degeneration (AMD)

A common condition causing deterioration of the macula, the central part of the retina responsible for sharp vision, leading to blurred or lost central vision.

How stem cells help:

 Stem cells may replace damaged retinal pigment epithelial cells, slowing the progression of vision loss and maintaining retinal health.

3. Pulmonary Diseases

Chronic lung diseases reduce respiratory function and quality of life, often caused by inflammation, fibrosis, or abnormal immune responses.

Chronic Obstructive Pulmonary Disease (COPD)

A group of lung diseases (including emphysema and chronic bronchitis) causing airflow obstruction, breathing difficulty, and chronic inflammation.

How stem cells help:

 MSCs can reduce lung inflammation and stimulate repair of alveoli (air sacs),improving lung function and slowing disease progression.

Interstitial Lung Diseases (ILD)

A group of disorders causing lung fibrosis (scarring) and impaired gas exchange, leading to breathlessness and chronic cough.

How stem cells help:

Stem cells may reduce fibrosis and promote healing of lung tissues, improving respiratory capacity.

Bronchopulmonary Dysplasia (BPD)

A chronic lung disorder mostly affecting premature infants with underdeveloped lungs, causing respiratory distress.

How stem cells help:

Stem cells support lung development and repair damaged tissue, helping improve lung function and growth.

Asthma

Achronic inflammatory disease of the airways causing wheezing, breathlessness, and coughing. Severe asthma may resist steroid treatment.

How stem cells help:

 MSCs have immunomodulatory effects, helping reduce airway inflammation and improve control in severe, steroid-resistant asthma cases.

4. Autoimmune and Inflammatory Conditions

These diseases happen when the immune system mistakenly attacks the body’s own tissues, causing chronic inflammation and tissue damage.

Crohn’s Disease

A chronic inflammatory bowel disease affecting any part of the gastrointestinal tract, causing abdominal pain, diarrhea, and weight loss.

How stem cells help:

Stem cells can promote healing of the intestinal lining and reduce inflammation, helping manage flare-ups especially in patients unresponsive to usual treatments.

Systemic Lupus Erythematosus (SLE)

A systemic autoimmune disease where immune attacks affect skin, joints, kidneys, and other organs.

How stem cells help:

MSCs suppress abnormal immune activity and inflammation, improving organ function and reducing symptoms.

Inflammatory Bowel Diseases (IBD)

Inflammatory Bowel Diseases (IBD) are chronic disorders that cause inflammation in the digestive tract, mainly including Crohn’s disease and ulcerative colitis. They can lead to symptoms such as abdominal pain, diarrhea, fatigue, and weight loss, and may cause long-term damage to the intestines if not properly managed.

How stem cells help:

Stem cells reduce mucosal inflammation and promote tissue repair, improving symptoms in refractory cases.

Post-transplant Graft-versus-Host Disease (GvHD)

 A complication of bone marrow or stem cell transplant where donor immune cells attack the recipient’s tissues.

How stem cells help:

 MSCs modulate immune cells to prevent or control this life-threatening condition.

5. Orthopedic and Musculoskeletal Disorders

Stem cells are key in repairing damage to bones, joints, cartilage, tendons, and ligaments, often caused by injury or degenerative diseases.

Osteoarthritis

Osteoarthritis is a degenerative joint condition where the protective cartilage that cushions the ends of bones gradually wears down. This leads to pain, stiffness, swelling, and reduced mobility, most often affecting the knees, hips, hands, and spine. It is the most common form of arthritis and typically worsens over time.

How stem cells help:

 Intra-articular injection of MSCs may regenerate cartilage, reduce pain, and improve joint function.

Rheumatoid Arthritis

Rheumatoid arthritis is a chronic autoimmune disorder in which the immune system attacks the lining of the joints, causing inflammation, pain, swelling, and stiffness. Over time, it can damage cartilage and bone, leading to joint deformity and loss of function. It can also affect other organs in the body.

How stem cells help:

 Stem cells reduce inflammation and may slow joint damage progression.

Tendon and Ligament Injuries

Tendon and ligament injuries occur when these connective tissues are stretched, torn, or damaged, often due to sudden trauma, overuse, or repetitive strain. Tendons connect muscles to bones, while ligaments connect bones to each other. Such injuries can cause pain, swelling, instability, and reduced mobility in the affected joint.

How stem cells help:

 MSCs accelerate healing and reduce recovery time by supporting tissue regeneration.

Osteonecrosis

Osteonecrosis is a condition where reduced blood flow to a bone causes bone tissue to die. This weakens the bone, can lead to collapse, and often results in joint pain and limited movement. It most commonly affects the hip, knee, shoulder, or ankle.

How stem cells help:

Early intervention with stem cells can regenerate bone tissue and prevent progression.

Degenerative Disc Disease

Degenerative Disc Disease (DDD) is the gradual wear and tear of the spine’s discs, causing loss of flexibility and cushioning. It can lead to back or neck pain and sometimes nerve-related symptoms like numbness or weakness. 

How stem cells help:

Injection of stem cells into discs may reduce pain and improve mobility by regenerating disc tissue.

Key Benefits of Stem Cell Therapy

Stem cell therapy is a promising area of regenerative medicine that offers significant benefits across various medical specialties. By harnessing the body’s natural ability to heal and repair itself, stem cells can play a key role in improving patients’ health outcomes.

• Tissue regeneration
  Stem cells can transform into different types of cells, which allows them to support the repair and regeneration of damaged tissues such as nerve cells, cartilage, muscle, or corneal tissue.

• Reduction of inflammation
  Stem cells release molecules that help control and reduce chronic inflammation, which is often at the core of many degenerative and autoimmune diseases.

• Immune system regulation
  In autoimmune disorders, stem cells help rebalance the immune system, reducing harmful responses without the need for long-term immunosuppressive treatments.

• Slowing the progression of disease
  In progressive conditions like Parkinson’s disease or multiple sclerosis, stem cell therapy may help protect existing cells and slow the deterioration of function.

• Improved functional outcomes
  Many patients experience improvements in mobility, vision, pain levels, breathing, or general energy, depending on the condition being treated.

• Reduced dependence on medications
  By addressing underlying mechanisms of disease, stem cell therapy can decrease the need for ongoing medication use and reduce associated side effects.

• Minimally invasive treatment
  Most stem cell therapies involve injections or infusions, offering a non-surgical approach with lower risks and shorter recovery times.

Safety, Ethics, and Protocols at Biruni Hospital

Patient safety is our top priority. All treatments at the Stem Cell Center at Biruni Hospital are conducted under strict ethical guidelines, scientific oversight, and regulatory compliance. We follow standardized protocols for stem cell harvesting, processing, and administration. Our laboratory facilities meet international accreditation standards for sterility, traceability, and quality control.

Each patient undergoes a comprehensive evaluation including medical history, diagnostic imaging, laboratory tests, and risk assessment before being approved for treatment. We also provide detailed follow-up care, monitoring outcomes and adjusting treatment as necessary.

Multidisciplinary Expertise and Personalized Care

Our Stem Cell Center is composed of a team of board-certified experts in neurology, pulmonology, orthopedics, immunology, ophthalmology, reproductive medicine, and regenerative biology. This allows us to create personalized treatment protocols based on each patient’s diagnosis, disease stage, age, lifestyle, and treatment goals.

We work hand in hand with our patients and their families to provide:

• Transparent information about risks and benefits
• A supportive and ethical decision-making process
• Ongoing education and rehabilitation support

Looking Ahead: The Future of Regenerative Medicine

Stem cell therapy continues to evolve rapidly. At Biruni Hospital, we remain committed to participating in clinical research and contributing to global knowledge in the field. We aim to expand our applications into other specialties such as dermatology, liver disease, and neurorehabilitation.We invite you to contact our Stem Cell Center for a personalized consultation.