Actinium-225 Therapy

Facing a cancer diagnosis is overwhelming, especially when standard treatments such as chemotherapy, radiation, or hormone therapy no longer work.

 At Biruni Hospital, we understand these challenges and are proud to offer Actinium-225 therapy, an advanced nuclear medicine treatment that gives new hope to patients with difficult-to-treat cancers.

Unlike conventional therapies, Actinium-225 targets cancer cells with remarkable precision, reducing side effects and improving outcomes. This approach is especially beneficial for patients who have exhausted standard options or whose cancers are resistant to other treatments.

The challenge of hard-to-treat cancers

Cancer remains one of the most complex diseases, and certain types present significant challenges:

• Advanced Prostate Cancer: Some patients develop resistance to hormone therapy or chemotherapy, leaving few effective options.
• Blood Cancers (Leukemia, Lymphoma): Standard treatments can cause severe side effects or may not fully control aggressive disease.
• Metastatic Cancers: When cancer spreads to bones, liver, or lungs, treatment becomes more difficult, and quality of life often declines.
• Recurrent or Resistant Tumors: Cancers that return after initial treatment can be more aggressive and less responsive to conventional therapies.

These situations create a need for more precise, powerful, and safer alternatives, and this is where Actinium-225 therapy plays a transformative role.

What makes Actinium-225 different?

Actinium-225 is a radioactive isotope that emits alpha particles, tiny, highly energetic particles that can destroy cancer cells while sparing nearby healthy tissues. 

Unlike radiation therapy that affects larger areas of the body, alpha particles travel only a very short distance (a few cell diameters). This makes Actinium-225 exceptionally precise.

At Biruni Hospital, our nuclear medicine team uses Actinium-225 by linking it to targeted molecules (such as antibodies or peptides) that naturally bind to cancer cells. Once delivered, Actinium-225 releases energy directly inside the tumor, causing cancer cell death without widespread damage.

Illnesses that can benefit from actinium-225 therapy

Actinium-225 therapy is designed to target cancer cells with precision, making it a valuable option for patients with advanced or difficult-to-treat cancers. 

At Biruni Hospital, we carefully assess each case to determine whether this therapy can provide the best possible outcomes.

Advanced Prostate Cancer

Prostate cancer is common in men, and while many respond well to surgery, hormone therapy, or chemotherapy, advanced cases may become resistant.

How Actinium-225 helps:

• Targets prostate-specific membrane antigen (PSMA) present on prostate cancer cells.
• Provides an option for patients whose cancer has spread to bones or lymph nodes.
• Reduces tumor burden and helps control symptoms such as bone pain.

Blood Cancers (Leukemia and Lymphoma)

Leukemia and lymphoma affect the blood and immune system, often requiring aggressive therapies that can weaken patients.

How Actinium-225 helps:

• Delivers treatment directly to malignant blood cells.
• Minimizes damage to bone marrow and healthy immune cells.
• Can be combined with existing therapies to improve effectiveness.

Neuroendocrine Tumors

These rare tumors grow slowly but can be difficult to treat once they spread.

How Actinium-225 helps:

• Targets specific receptors on neuroendocrine tumor cells.
• Provides longer-lasting control compared to conventional radiotherapy.

Other Solid Tumors (under Clinical Trials)

Research is expanding the use of Actinium-225 in cancers such as breast, ovarian, and gliomas. Patients at Biruni Hospital may have access to these therapies through clinical trials, offering innovative treatment opportunities.

Benefits of Actinium-225 Therapy

Actinium-225 therapy offers a precise and powerful approach to treating certain cancers, especially when conventional treatments are less effective. Key benefits include:

• Targeted Action: Destroys cancer cells while sparing healthy tissues.
• Effective for Resistant Cancers: Provides new options when chemotherapy or radiation have limited effect.
• Fewer Side Effects: Generally better tolerated than traditional treatments.
• High Potency: Small doses deliver powerful energy directly to tumors.
• Personalized Care: Treatment plans are tailored to each patient’s cancer type and overall health.

This therapy gives patients a safer, more precise, and more effective option for advanced or difficult-to-treat cancers.

Learn more aboutActinium-225 Therapy

Why Choose Biruni Hospital for Actinium-225 Therapy?

• Expertise in Nuclear Medicine: Our doctors are among the few trained in advanced radionuclide therapy.
• Cutting-edge Facilities: Equipped with state-of-the-art imaging and treatment technologies.
• Holistic Cancer Care: Beyond the therapy itself, we offer multidisciplinary care, including oncology, radiology, and supportive services.
• International Patient Services: Dedicated support for patients traveling from abroad, including translation, accommodation, and coordination of care.
• Access to Clinical Trials: Opportunity to benefit from the latest global research and emerging therapies.

A New Chapter in Cancer Treatment

Actinium-225 therapy represents a breakthrough in modern oncology. By delivering powerful radiation directly to cancer cells while protecting healthy tissues, it opens new possibilities for patients with advanced or resistant cancers.

At Biruni Hospital, we combine expertise, innovation, and compassion to ensure patients receive world-class care.Whether you are exploring new options after conventional treatments or considering participation in clinical trials, Actinium-225 therapy may be the right step for your cancer journey.